MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
نویسندگان
چکیده
منابع مشابه
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.
Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins. This microRNA has been implicated in various aspects of carcinogenesis, including cellular proliferation, apoptosis, and migration. We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, ...
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1 Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA. 3 Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massach...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2008
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00479-08